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Updated: Sep 12, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

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V(D) J 再結合による切除されたDNA円は,再発性白血病を促進する

Zeqian Gao1, James N F Scott1, Matthew P Edwards1,2

  • 1School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|August 6, 2025
PubMed
まとめ

切断されたシグナルサークル (ESC) は,V(D) J再結合の副産物で,以前考えられていたとは異なり,複製され持続します. 増加したESCはB細胞急性リンパ性白血病の再発と相関しており,悪性がんのアウトカムにおける役割を果たしていることを示している.

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