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関連する概念動画

Translational Regulation01:29

Translational Regulation

94
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
94
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

7.6K
Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
7.6K
Leaky Scanning02:28

Leaky Scanning

5.2K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Post-translational Translocation of Proteins to the RER01:27

Post-translational Translocation of Proteins to the RER

5.9K
A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
Targeting proteins to the ER
Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
5.9K
Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Genomics02:02

Genomics

37.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
37.5K

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Updated: Sep 12, 2025

Working with Human Tissues for Translational Cancer Research
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Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

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ゲロサイエンス: 翻訳的レビュー

Stephen B Kritchevsky1, Steven R Cummings2,3

  • 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, and the Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University of School of Medicine, Winston-Salem, North Carolina.

JAMA
|August 7, 2025
PubMed
まとめ
この要約は機械生成です。

ゲロサイエンスでは 老化経路をターゲットに 老化に関連する病気や障害を予防します カロリー制限や老化剤のような治療は 健康と寿命を延ばす 可能性を示しています

さらに関連する動画

TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos
10:26

TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos

Published on: September 10, 2015

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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
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関連する実験動画

Last Updated: Sep 12, 2025

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.0K
TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos
10:26

TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos

Published on: September 10, 2015

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A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
09:35

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

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科学分野:

  • ゲロサイエンス
  • 老化生物学
  • ゲロントロジー

背景:

  • 脳卒中,心不全,がんなどの年齢関連の疾患は 年齢とともに増加します
  • 現在の医療療法では 特定の病気を標的として 治療していますが 老化過程自体には 影響はありません
  • 動物実験では 老化を遅らせ,健康状態を改善することが示されています.

研究 の 目的:

  • ゲロサイエンスが 老化経路を変える可能性を 探求すること
  • 年齢関連の病気や機能低下を遅らせる治療法を研究する.
  • 障害のない生存率を 老化介入によって増加させる

主な方法:

  • ゲロサイエンスと高齢化介入に関する既存の文献のレビュー
  • カロリー制限,ラパミシン,セノリチクに関する動物モデル研究の分析.
  • 老化バイオマーカーと介入に関するヒトの研究の検討

主要な成果:

  • カロリー制限とラパミシンは 寿命を延ばし 健康を改善しました
  • 衰老細胞は年齢とともに蓄積し 身体的障害や死亡率と相関しています
  • 生物学的老化を対象とした介入は 人々の健康に有益な可能性を 示しています

結論:

  • カロリー制限,メトホルミン,老化剤,ラパラグを含む老化生物学を阻害する治療は,病気の進行を遅らせる可能性があります.
  • ゲロサイエンスは 複数の年齢関連の疾患を 同時に予防し 治療するための 新しいアプローチを提供します
  • 人間の老化細胞の減少の健康上の利点を明らかにするためにさらなる研究が必要である.