脳と肝臓の軸のヴァーガル阻害は,がんに関連したカシェキアを抑える

Aliesha Garrett¹, Naama Darzi², Ashlesha Deshmukh³

¹Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA; Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cell

|August 8, 2025

まとめ

ガンに関連したカシェキア (CAC) は,脳と肝臓の軸をバグス神経経由で破壊する炎症を伴う. この神経を標的にすることでカケキシアを軽減し,症状を緩和し,化学療法効果を高めることができます.

科学分野:

腫瘍学
神経科学
代謝疾患

背景:

癌に関連したカシェキア (CAC) は,がんによる死亡率と治療抵抗に寄与する複雑な症候群である.
癌患者の全身性炎症は既知の要因ですが,特定の神経経路への直接的な影響はまだ調査中です.

研究の目的:

ガンによるカシェキシアにおけるヴァーガル神経の信号伝達の役割を調べるため
肝臓の代謝と全身の炎症に対する管調節障害の影響を調べる
CACの治療のために迷走神経を標的とした治療戦略を評価する.

主な方法:

癌に関連したカシェキシアのマウスモデルを使用した.
全身の炎症と静脈の調節の変化を評価した.
肝臓のタンパク質代謝とHNF4α発現を分析した.
右頸動脈の介入 (外科的,化学的,電気的,皮膚経由)

主要な成果:

癌によって引き起こされる炎症は,CACモデルで脳と肝臓の軸を乱します.
肝臓の代謝を再プログラムし,炎症を促進します.
CACの進行と臨床症状を弱めた.
ネズミの生存率を向上させた.

結論:

迷走神経は脳と肝臓の軸を通して癌に関連したカシェキアを媒介する上で重要な役割を果たします
神経活性の調節は,CACに対する有望な治療戦略です.
非侵襲的な神経刺激は癌治療に役立つかもしれません

キーワード:

HNF4α について癌に関連したカシェキア肝臓メタボリズム神経調節迷走神経

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