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Updated: Sep 11, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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アルキリデネ・サイクロプロパンの触媒的エナント選択合成

Jonathan C Golec1,2, Dong-Hang Tan1, Ken Yamazaki1,3,4

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, UK.

Nature
|August 11, 2025
PubMed
まとめ

この研究では,二機能イミノフォスフォラン触媒を用いて,エナティオメリで濃縮されたアルキリデネサイクロプロパン (ACP) を合成するための新しい方法が導入されています. この発見により 医薬品や農薬に含まれる 価値あるサイクロプロパン構造物へのアクセスが 容易になりました

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