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Updated: Sep 11, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Published on: September 18, 2014

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NIR-スイッチドDNAシャッターは,反転可能な中断的なcGAS-STING活性化により,抗腫瘍免疫が強化されます

Shiyi Bi1, Ruowen Yang1, Yulin Cong1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society
|August 18, 2025
PubMed
まとめ

この研究は,免疫療法のための中断性STINGアゴニストを導入します. この新しいアプローチは,免疫反応と腫瘍細胞の殺戮を強化し,継続的な経路刺激に関連する抵抗を克服するために,可逆的な活性化を使用します.

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