Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.9K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.9K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
Abnormal Proliferation02:23

Abnormal Proliferation

4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物医学と臨床科学
  7. 腫瘍学とがん発生
  9. 予測・予測マーカー
  11. Poc1aは,三重陰性乳癌のstat3信号経路を通じた成長と転移を促進するために上皮質-メゼンキマの移行を誘導する.

POC1Aは,三重陰性乳癌のSTAT3信号経路を通じた成長と転移を促進するために上皮質-メゼンキマの移行を誘導する.

Yuzhou Qian1,2, Yu Che1, Shanqi Li2

  • 1Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, China.

Molecular medicine (Cambridge, Mass.)
|August 20, 2025

関連する実験動画

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.0K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.3K
The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior
08:12

The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior

Published on: June 12, 2019

5.2K

PubMed で要約を見る

まとめ
この要約は機械生成です。

POC1Aタンパク質は,上皮-メゼンキマ移行 (EMT) を誘導することによって,三重陰性乳がん (TNBC) の転移を促進します. この研究では,POC1AがTNBCの侵入における重要なレギュラーであり,STAT3経路を強調しています.

科学分野:

  • 腫瘍学
  • 分子生物学
  • 癌 研究

背景:

  • トリプルネガティブ乳がん (TNBC) は,異質性,転移,侵入を含む攻撃的な行動によって特徴付けられます.
  • POC1中心型タンパク質ホモログA (POC1A) は,様々な癌に関与する中心型タンパク質ですが,TNBC転移におけるその役割は不明です.
  • TNBCの転移におけるPOC1Aのメカニズムを理解することは,標的治療の開発に不可欠です.

研究 の 目的:

  • TNBCにおけるPOC1Aの発現と臨床的意義を調査する.
  • POC1AがTNBCの表皮細胞-メゼンキーマ移行 (EMT),侵入,転移を調節する役割を解明する.
  • POC1A媒介のTNBC転移に関与する信号経路を特定する.

主な方法:

  • TNBC組織と細胞系におけるPOC1A発現を分析した.
  • 免疫光,RT-qPCR,およびウェスタン・ブロッティングを用いて,EMTマーカーに対するPOC1Aの影響を評価した.
  • 異種移植モデルを用いて,TNBC細胞の移動と侵入を in vitro と in vivo で評価した.
  • 関連するシグナル伝達経路を特定するためにRNAシーケンシング (RNA-seq) を利用した.

主要な成果:

  • POC1Aの発現はTNBC組織で上昇し,腫瘍サイズとリンパ節転移と相関しています.
キーワード:
EMT についてメタスタシスPOC1ASTAT3 について

関連する実験動画

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

36.0K
Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

13.3K
The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior
08:12

The Use of Mouse Mammary Tumor Cells in an In Vitro Invasion Assay as a Measure of Oncogenic Cell Behavior

Published on: June 12, 2019

5.2K
  • POC1Aは,EMTを調節することにより,TNBC細胞の侵入と転移をインビトロおよびインビボで有意に促進する.
  • RNA-seq分析により,STAT3シグナル伝達経路がPOC1A誘発のEMTと転移の主要なメディエーターとして特定されました.

    • 結論:

    • POC1AはTNBCにおけるEMTの重要なレギュレータとして特定されています.
    • POC1AはSTAT3信号経路を通じてTNBC転移を促進する.
    • POC1Aを標的とした治療はTNBCの新たな治療戦略である可能性があります.
    TNBC について