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Updated: Sep 10, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.0K

KAT6Aキメラは,NURFとMLL/COMPASSで自己強化の表遺伝子モジュールを形成し,AMLを維持する

Junhui Lv1, Zhinang Yin1, Conghui Li1

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, TaiKang Center for Life and Medical Sciences, School of Basic Medical Sciences, Wuhan University, 115 DongHu Road, Research Building III, Room 404, Wuchang District, Wuhan, 430071, China.

Genome biology
|August 20, 2025
PubMed
まとめ

急性骨髄性白血病 (AML) のKAT6A融合は予後が悪いことと関連しています. この研究では,KAT6A,NURF,MLL/COMPASSを含む新しい表遺伝子モジュールを明らかにし,AMLに対する有望な治療戦略として,NURFまたはCBP/P300抑制を特定しました.

キーワード:
AML について急性骨髄性白血病クロマチンアクセシビリティKAT6AKAT6A-CBP についてKAT6A-P300 についてMLL/COMPASS についてNURF について核粒子の改造因子

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