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Updated: Sep 10, 2025

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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ID-LC-MS/MSを用いたプラズマクロザピンの定量化のための候補基準測定手順の開発と検証

Xiaodong Yang1, Minmin Tu1, Chunlan Tang2

  • 1Reference Laboratory, Medical System Biotechnology Co., Ltd., Ningbo, Zhejiang, China.

Journal of mass spectrometry : JMS
|August 20, 2025
PubMed
まとめ

新しい候補基準測定法 (cRMP) は,同位体希釈液体染色体-タンデム質量スペクトロメトリを用いて,ヒトの血におけるクロザピン (CLO) を正確に定量化します. この検証された方法は,治療薬モニタリング (TDM) を強化し,患者の安全性と臨床結果を改善します.

キーワード:
ID-LCMS/MS分析性能についてクロザピン測定の不確実性治療薬モニタリングトレーサビリティ

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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