バルプロアート療法を受けた患者における,過剰な症状のサブクリニック性甲状腺機能低下症:症例報告
Samarth Doshi1, Kelly A Denhard2, Kathryn Li Xixis3
1Department of Pediatrics, Northwestern University's Feinberg School of Medicine and The Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Journal of child neurology
|August 20, 2025
まとめ
バルプロアート治療はサブクリニック性甲状腺機能低下を引き起こす可能性があります. この症例は,バルプロアートの希少だが有害な効果を示した 明らかに甲状腺機能低下の症状を経験した小児患者の例です.
科学分野:
- 小児内分泌学
- 神経学
- 薬理学について
背景:
- ヴァルプロアートは,サブクリニカルな甲状腺機能低下症との潜在的な関連を含むホルモン機能障害と関連しています.
- 現存する文献では,その関連性について議論されており,ほとんどの研究では,サブクリニカルな甲状腺機能低下症と共に,明らかな甲状腺機能低下症の症状が報告されていない.
研究 の 目的:
- 長期にわたってバルプロアート治療を受けた小児の一般性の症例で,明らかに症状のあるサブクリニック性甲状腺機能低下症を発症した.
- バルプロアートの副作用として,症状のあるサブクリニック性甲状腺機能低下の可能性を強調する.
主な方法:
- バルプロアート単独療法を受けた3歳の小児患者による症例報告
- 2年間の治療で甲状腺機能と臨床症状のモニタリング
- 症状と検査結果に基づいて,グレード2のサブクリニック性甲状腺機能低下症の診断
主要な成果:
- バルプロアート治療の2年以上後,患者は明らかに甲状腺機能低下の症状を発症した.
- 準臨床的甲状腺機能低下症の診断が確認されました.
- 症状はバルプロアートを中止し,レボチロキシン治療を開始すると消えた.
結論:
- サブクリニック性甲状腺機能低下は,バルプロアートの認められた有害作用です.
- この症例は,ヴァルプロアートを投与する小児の患者に,希少ではあるが,明らかな甲状腺機能低下の症状が現れることを強調しています.
- 治療はバルプロアートとレボチロキシンを停止し,甲状腺機能の正常化と症状の解消につながった.
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