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Updated: Sep 10, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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MEKとmTORの併用不活性化により,GlioblastomaモデルおよびNF1欠乏症およびメセンキマサブタイプに関連するシナギスティック細胞死を引き起こす

Fleur M G Cornelissen1, Yoran Broersma1, Ravi S Narayan1

  • 1Department of Neurosurgery, Cancer Center Amsterdam, Amsterdam UMC location VUMC, Amsterdam, the Netherlands.

Molecular cancer therapeutics
|August 20, 2025
PubMed
まとめ

MEKとmTORの二重抑制は,特にNF1欠乏症およびメゼンキマサブタイプにおける,芽細胞腫 (GB) の治療に有望である. この併用療法により,脳腫瘍の成長が長期間抑制されます.

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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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