パーキンソン病に関連する慢性疼痛と関連のない慢性疼痛の区別と相互の影響

Jonathan Hunger¹, Florian Brugger², Georg Kägi^2,3

¹Department of Neurology, Center for Neurorehabilitation, Valens, Switzerland.

Movement disorders clinical practice

|August 20, 2025

まとめ

慢性的な痛みはパーキンソン病 (PD) に共通しています. PDの痛み分類システム (PD-PCS) は,PDに関連する痛みを他の痛みタイプと区別し,治療決定に役立ちます.

科学分野:

神経科学
痛みの治療
パーキンソン病の研究

背景:

慢性的な痛みはパーキンソン病 (PD) の一般的な非運動症状です.
PDに関連した痛みの正確な診断は,効果的な患者管理と治療戦略に不可欠です.

研究の目的:

PD関連痛みの診断のためのPD痛みの分類システム (PD-PCS) を評価する.
パーキンソン病の患者におけるパーキンソン病に関連した痛みと,パーキンソン病に関連していない痛みとの相互作用を調査する.

主な方法:

120人の非認知症患者の多センター研究
患者の評価のためにPD-PCS,モーター,およびノンモーターのアンケートを使用しました.
PD-PCSは,PDとの関係性,痛みメカニズム,およびスコアを分類することを含む.

主要な成果:

患者の92%が慢性的な痛みを経験し,73%がPDに関連した痛みを経験し,53%がPDに関連しない痛みを経験した.
高いPD-PCSスコアはPDに関連した痛みの存在と相関しています.
ドーパミン作用薬による痛み改善と"オフ"期間の痛みはPDに関連する痛みの主要な指標でした.

結論:

PD-PCSはPDに関連した慢性疼痛とPDに関連していない慢性疼痛を効果的に区別します.
PDに関連しない痛みは,PD患者において一般的であり,PD関連痛みに影響することがあります.
総合的な治療の際には,PDに関連した痛みと,PDに関連していない痛みの両方を考慮する必要があります.

キーワード:

PD に関する痛み PD に関係ない痛みパーキンソン病慢性的な痛み非運動症状

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