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関連する概念動画

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

146
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
146
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

185
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
185
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

947
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Human Genetics01:28

Human Genetics

719
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
719
Schizophrenia01:17

Schizophrenia

217
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
217
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

289
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
289
このページは機械翻訳されています。他のページは英語で表示される場合があります。View in English
  1. ホーム
  3. 研究分野
  5. 生物学的科学
  7. 遺伝学
  9. エピジェネティクス (ゲノムメチレーションとエピジェノミクスを含む)
  11. 統合失調症に関連したリスク遺伝子の脳機能ネットワークと幹部欠陥への影響:統合失調症と遺伝的高リスクの個体に関する研究

統合失調症に関連したリスク遺伝子の脳機能ネットワークと幹部欠陥への影響:統合失調症と遺伝的高リスクの個体に関する研究

Ting Sun1, Yue Zhu2, Pengfei Zhao2

  • 1Department of Psychiatry, https://ror.org/0202bj006Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Psychological medicine
|August 20, 2025

関連する実験動画

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

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Development of a Virtual Reality Assessment of Everyday Living Skills
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Development of a Virtual Reality Assessment of Everyday Living Skills

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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PubMed で要約を見る

まとめ
この要約は機械生成です。

統合失調症 (SCZ) と高リスクの個人は,執行機能の欠陥に対する遺伝的リスク効果を媒介する帯状管機能の障害を示します. これはSCZにおける 神経認知の重要なリンクを明らかにします

科学分野:

  • 神経科学
  • 精神科
  • 遺伝学

背景:

  • 統合失調症 (SCZ) と遺伝的高リスク (GHR) の個人は認知の欠陥と脳のネットワークの変化を示します.
  • SCZリスク遺伝子はこれらの障害に寄与する可能性があります.

研究 の 目的:

  • SCZとGHRの個体における脳ネットワークと実行機能の障害を特定する.
  • これらの欠陥に対するSCZリスク遺伝子の影響を調査する.

主な方法:

  • 休息状態の機能MRI (rs- fMRI) とウィスコンシンカードソートテスト (WCST) を292人の参加者 (SCZ,GHR,健康な対照群) で使用した.
  • SCZ関連ポリジェニックリスクスコア (SCZ-PRS) を計算し,遺伝的リスクを評価する.

主要な成果:

  • SCZとGHR群では,右帯状/パラ帯状回転 (MCPG_R) の節節効率と集中度 (Dnodal) の低下が確認された.
  • SCZ-PRS,MCPG_RにおけるDnodal,およびWCSTのスコアは有意に相関していました.
  • MCPG_RのDnodalは,SCZ-PRSと実行機能の間のリンクを媒介しました.

結論:

  • 遺伝的リスクがSCZにおける実行機能の欠陥にどのように影響するかには,帯状皮質機能の障害が中心です.
キーワード:
脳のネットワーク認知機能機能神経イメージング

関連する実験動画

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.0K
Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.7K
  • 発見は,SCZの遺伝子神経認知機構と潜在的な治療目標の洞察を提供します.
    • 多遺伝子リスクスコア
    統合失調症