同診の双方向内視鏡検査を受ける高齢者のプロポホル鎮静剤としての静脈内リドカイン:多センターランダム化制御試験のプロトコル
Ying Liu1,2, Nan Song1,2, Jing-Tao Zhang1,3
1Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China.
Annals of medicine
|August 20, 2025
まとめ
この研究では,静脈注射されたリドカインが,双方向内視鏡検査を受ける高齢者のプロポフォール鎮静療法中の有害事象を減少させるかどうかを調査した. 結果は,この集団の鎮静を最適化することを目的としています.
科学分野:
- 麻酔科
- 胃腸内科
- 高齢者医療
背景:
- 高齢の患者は,同診の双方向内視鏡検査を鎮静剤で頻繁に受けます.
- この人群の最適の鎮静療法は不明である.
- 内視鏡検査を受ける高齢者の場合,鎮静関連の有害事象が懸念される.
研究 の 目的:
- 静脈内投与のリドカインがプロポフール鎮静剤の補助剤として,双方向内視鏡検査を受ける高齢患者の有害事象を減少させるかどうかを評価する.
- リドカインが手術中の不飽和と低血圧を減少させるという仮説を検証する.
主な方法:
- 648人の高齢者を対象とした多センター,ランダム化,ダブルブラインド,プラセボ対照試験です.
- 患者は,静脈内リドカインまたは通常の塩分液 (プラセボ) を併用して,スフェンタニルとプロポポールを投与された.
- 主要アウトカム: 脱飽和 (SpO2 < 90%) と低血圧 (SBP < 90 mmHg または > 20% の低下) の複合値
主要な成果:
- この研究は現在,患者の登録を進めており,結果は待機中です.
- リドカインとプラセボのグループ間の脱飽和と低血圧の発生率を比較します.
- 二次的アウトカムにはプロポポールの投与量,身体の動き,痛み,疲労,回復時間が含まれます.
結論:
- 補助的なリドカインは,双方向内視鏡検査を受ける高齢者のプロポホル鎮静を最適化することができる.
- この発見は,この脆弱な患者群の鎮静策を参考にすると予想されます.
- この研究は高齢者の鎮静療法における 重要なギャップを解決するものです
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