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Updated: Sep 8, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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ソトラジブとその主要代謝産物に対する肝障害の臨床的影響: 投与量調整への影響

Mason McComb1, Panli Cardona1, Caitlin Sampson1

  • 1Amgen Inc., Thousand Oaks, CA, USA.

Journal of clinical pharmacology
|August 20, 2025
PubMed
まとめ

非小細胞肺がんのKRAS G12C阻害剤であるソトラジブは,中度または重度の肝機能障害の患者で有意な薬理学的な変化を示さなかった. これらの患者群では用量調整は不要です.

キーワード:
肝臓障害メタボライト薬理学タンパク質結合ソトラシブ

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