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Updated: Sep 8, 2025

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein
09:59

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

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CFTR活性強化の熱力学的基礎

Guangyu Wang

    Research square
    |August 20, 2025
    PubMed
    まとめ

    トリカフタ調節剤は,核酸結合ドメインの二分化を安定させることで,システィック線維症の膜伝導性調節器 (hCFTR) の機能を強化する. NBD1とNBD2の間の比較可能な熱安定性は,CFTR機能を改善するVX-770の強化に不可欠です.

    キーワード:
    アロステリックカップリングデジタル生物学領域間の相互作用最低安定相互作用リガンド調節溶ける値タンパク質の安定性熱力学シグネチャーサーモリング

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