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アミトリプチリンは,D614G,オミクロンBA.5およびオミクロンXBB.1を含む異なるSARS-CoV-2変種を強力に中和します
Isabel Zydek1, Laura Thümmler1, Nadine Beckmann2
1Department of Infectious Diseases, West German Centre of Infectious Diseases, University Medicine Essen, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Frontiers in microbiology
|August 20, 2025
まとめ
抗うつ薬であるアミトリプチリンは,オミクロンなどの変種を含むSARS-CoV-2を効果的に中和します. この再利用された薬は,特に資源が限られているところでは,COVID-19の治療に有望な効果を示しています.
科学分野:
- ウイルス学
- 薬理学について
背景:
- COVID-19 (SARS-CoV-2) は,免疫脱出変種と長期COVIDにより複雑化した世界的な健康問題であり続けています.
- アシドスフィンゴミエリンゼの機能性阻害剤 (FIASMA) は,潜在的に広範囲の抗ウイルス作用を有する.
研究 の 目的:
- 既知のFIASMAであるアミトリプチリンのSARS-CoV-2に対する抗ウイルス効果を評価する.
- COVID-19の新たな治療薬としてのアミトリプチリンの可能性を評価する.
主な方法:
- 擬似ウイルス型の粒子 (VLP) と臨床的なSARS-CoV-2単離体を使用して,インビトロ中和測定を行った.
- ウイルス侵入と複製の抑制を測定することで抗ウイルス活性が評価されました.
主要な成果:
- アミトリプチリンは,スパイクタンパク質の変異を含むSARS-CoV-2 VLPの有意な阻害を示した.
- この薬は,D614G,オミクロンBA.5およびオミクロンXBB.1の複製を,毒性のない濃度で減少させた.
結論:
- アミトリプチリンは,複数の変種でSARS-CoV-2を効果的に中和します.
- 結果は,COVID-19に対する再利用された抗ウイルス薬としてのアミトリプチリンの可能性を裏付けています.
- ヒトでの有効性と安全性を確認するには,さらなる臨床試験が必要である.
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