閉経前と閉経後の婦人科の外科医の間で年齢関連の陰道微生学と感染症疫学:横断的な研究
Wenyu Lin1,2,3, Liying Wang1,2,3, Binhua Dong1,2,3
1Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.
Frontiers in cellular and infection microbiology
|August 20, 2025
まとめ
閉経後のエストロゲンの減少は陰道の健康に影響し,細菌性陰道炎 (BV) と有酸素性陰道炎 (AV) を増加させ,酵母菌感染症を減少させます. 効果的な臨床管理のために,陰道微生物群,酵素,代謝物の年齢関連の変化を考慮する必要があります.
科学分野:
- 婦人科
- 微生物学
- メタボロミクス
背景:
- 閉経後のエストロゲン欠乏症は の微生物学的バランスを乱します
- 婦人科の外科医では 陰道感染や微生物群の変化が一般的です
研究 の 目的:
- 陰道感染症の流行病学と,更年期前および更年期後の女性の微生物組成,酵素および代謝物の変化を調査する.
- 年齢によるエストロゲンの変化が の微生物に与える影響を 理解するためです
主な方法:
- 27,346人の女性 (2018年−2023年) の陰道微生学データを分析した横断的な研究.
- 陰道の清潔さ,細菌の密度,多様性の体系的な評価
- 20人の被験者 (10人の閉経前,10人の閉経後) の非ターゲットのLC-MS代謝分析
主要な成果:
- 閉経後の女性はバクテリア性陰道炎 (BV) とエアロビック性陰道炎 (AV) の有病率が高く,ヴァルボヴァギナルカンジダース (VVC) の有病率は低かった.
- 閉経後の女性では,BV関連バイオマーカーと炎症マーカーの上昇が観察されました.
- メタボロミック分析では,チェノデオキシコール酸グリシン結合の増加とO- フォスフォトレオニン,モルフォリン,およびダイエタノラミンの減少が閉経後の女性で示されました.
結論:
- 年齢は,感染流行病学,微生物群,酵素,代謝産物に影響を及ぼし,陰道微生態学に大きな影響を与えます.
- 臨床的介入は,年齢に関連するエストロゲン変化を考慮して,陰道の健康を効果的に管理する必要があります.
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