術後感染の整形外科患者におけるラインゾリド誘発のグロシトとパピリト: 症例報告
Ryan J Blake1, Benjamin M Frye1,2, Allison M Lastinger1,2,3
1Department of Orthopaedic Surgery, West Virginia University, Morgantown, West Virginia, USA.
Case reports in infectious diseases
|August 20, 2025
まとめ
リネゾリドの抗生物質治療は,短期間の使用でも,舌の腫れや痛みなどの異常な経口副作用を引き起こす可能性があります. この研究は,典型的な黒い毛のある舌の表現を超えた非典型的な反応を強調しています.
科学分野:
- 感染症
- 薬理学について
- 口腔医学
背景:
- ラインゾリドは,グラム陽性細菌感染症に対して有効なオクサゾリドニノン抗生物質です.
- 皮膚,骨,軟組織の感染症に一般的に処方される.
- 既知の副作用には,血液学的および神経学的毒性が含まれています.
研究 の 目的:
- 短期間のラインゾリド使用に関連した非典型の経口副作用の3つの症例を報告する.
- 典型的な黒い毛のある舌の表情のない口腔の痛みと光炎/乳頭炎を記述する.
- 新しいラインゾリド誘発の口服不良症状のモニタリングの重要性を強調する.
主な方法:
- ラインゾリドで治療された3人の整形外科患者のケースシリーズ.
- 口腔の症状の臨床観察 痛みや周回頭皮の腫れなど
- 同症状を引き起こす可能性のある共感染と併用薬の排除.
主要な成果:
- 3人の患者は,ラインゾリドを10日間服用した後,口腔の痛みと環状乳房の腫れを発症した.
- 症状は特徴的な黒い毛のある舌の変色なしでした.
- 短期的な治療にもかかわらず,薬物毒性または中性不全の兆候は観察されなかった.
結論:
- ラインゾリドは,短期間の使用でも,一般化された光炎やパピル炎を誘発する可能性があります.
- これらの口腔の副作用は,以前報告された黒い毛のある舌とは異なることがあります.
- 臨床医は,ラインゾリドの治療中に非典型の口腔症状をモニタリングする必要があります.
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