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Updated: May 7, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
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MCPyV ALTOの短い本質的に乱れたドメインは,ホストTBK1のシグナル伝達とMCPyVの遅延を調節する

Taylor E Senay, Xiaomei Li, Sneha G Shirhattikar

    bioRxiv : the preprint server for biology
    |August 20, 2025
    PubMed
    まとめ

    メルケル細胞ポリオマウイルス (MCPyV) は,そのALTOタンパク質を使用して宿主の免疫反応を抑制し,生涯にわたる感染症を維持します. ALTOで新たに特定されたLITドメインは,この免疫回避に不可欠であり,メルケル細胞癌の潜在的な治療標的を提供します.

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