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Updated: Sep 8, 2025

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調節システムの結合作用はコリスチンヘテロレジスタンスを生成する

Jacob E Choby1,2,3, Emily K Crispell1,2,3, Muqing Ma1,4

  • 1Emory Antibiotic Resistance Center, Atlanta, GA, USA.

bioRxiv : the preprint server for biology
|August 20, 2025
PubMed
まとめ

シグマ因子 σEは,Enterobacter cloacae集団内のコリスチン抵抗性の異質性を生み出します. この異質性は,PhoPQシステムの活動と組み合わせて,コリスチン抗生物質に対する生存に不可欠です.

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Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...
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