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関連する概念動画

Synteny and Evolution02:31

Synteny and Evolution

3.4K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.4K
Convergent Evolution01:54

Convergent Evolution

28.9K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
28.9K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.3K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.3K
Exon Recombination02:32

Exon Recombination

3.7K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.4K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.4K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.3K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.3K

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関連する実験動画

Updated: Sep 8, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

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類人猿のアミラーゼロカスにおける独立した再配置による収束進化

Charikleia Karageorgiou1, Stefan Ruhl2, Omer Gokcumen1

  • 1Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA.

bioRxiv : the preprint server for biology
|August 20, 2025
PubMed
まとめ

構造的に複雑なゲノム領域は 繰り返しの遺伝子複製を通して 進化的収束を促します これらの複製はレトロトランスポゾンによって開始され,再結合によって駆動され,霊長類における新しい遺伝子発現パターンと機能的分岐につながります.

科学分野:

  • ゲノミクス
  • 進化生物学
  • 分子 進化

背景:

  • 構造的に複雑なゲノム領域は 進化的収束の主要な原動力であり,しばしば 繰り返しの遺伝子複製を通して起こる.
  • これらの重複の背後にあるメカニズムと新しい表現パターンを可能にする規制の変更はよく理解されていません.
  • 独立した遺伝子の複製の歴史を持つ霊長類のアミラーゼは 優れたモデルシステムとして機能します

研究 の 目的:

  • 類人猿のアミラーゼの複製の進化史を再構築する.
  • これらの重複を誘発する突然変異のメカニズムと,変異した遺伝子発現に関連した規制的変化を調査する.
  • 複雑なゲノム領域における構造的および規制的変化が,進化的革新と分子収束にどのように貢献するのかを理解する.

主な方法:

  • 53種の霊長類の高品質のゲノムアセンブリを比較したゲノム分析
  • 旧世界猿の多組織トランスクリプトームの分析
  • 遺伝子の複製を図形的に再構築する
  • プロモーター地域を分析し,規制モチーフの売上を特定する.

主要な成果:

  • 系統特異のLTRレトロトランポゾン挿入は,初期ゲノム不安定と関連しており,その後の重複を誘発する非アレル同種再結合が続く.

さらに関連する動画

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.9K

関連する実験動画

Last Updated: Sep 8, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.0K
CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

11.7K
Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp
10:44

Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

Published on: June 20, 2018

9.9K
  • アミラーゼ遺伝子の独立複製はマカク,バビオン,大類人猿で発生し, 臓と唾液腺に収束発現を引き起こした.
  • エピソード的多様化選択は,系統特有のアミラーゼコピーに作用し,機能的分散を促進しました.
  • 比較分析により,霊長類のアミラーゼプロモーター領域における構造的再編成とモチーフの周回が媒介され,発現における進化的シフトが明らかになった.
  • 結論:

    • 複雑なゲノム領域における構造的および規制的モジュラリティは,進化的革新と分子収束を容易にする.
    • LTRレトロトランスポゾンと同種の再結合は,再発的な遺伝子複製を促す重要なメカニズムです.
    • 構造的な変化に起因する 規制の再編成は 遺伝子発現パターンの進化において 重要な役割を果たします
    • 霊長類のアミラーゼロキュスは,進化過程のゲノム基盤を解剖するためのモデルを提供します.