視覚皮質における試験対試験のスパイクカウントの変動のグローバルとローカルな起源
Anna J Li1, Ziyu Lu2, Alexander E Ladd1
1Department of Neurobiology and Biophysics, University of Washington, Seattle, WA, USA.
bioRxiv : the preprint server for biology
|August 20, 2025
まとめ
視覚野の神経活動の変動は 局所的な活動や行動ではなく グローバルな脳信号に影響されます これらの全体的な要因は 視覚皮質のニューロンにおける 試験間での違いを 以前考えられていたより多く説明します
科学分野:
- 神経科学
- 計算神経科学
- システム神経科学
背景:
- 感覚ニューロンの反応は,神経活動,興奮,運動からの貢献とともに,試験から試験への変化を示す.
- この変動が基底の信号に対するノイズを表す程度は不明である.
- 全球的な脳活動パターンは,視覚皮質ニューロン反応の追加的な変動を説明する可能性があります.
研究 の 目的:
- マウスの主視野皮質 (V1) のピーク数における試験対試験の変動に対する全体的な皮質活動パターンの寄与を調査する.
- V1応答の行動要因と対比して,グローバル活動の説明力を区別する.
- 局所的な回路と非局所的な源によるV1の変動の範囲を決定する.
主な方法:
- ネイロピクセル2. 0の探査機を使ってマウスV1の神経活動を記録した.
- 前帯状領域 (ACA) または背皮の広場カルシウム信号から同時に行動データと神経活動を記録します.
- V1のスパイク数で説明可能な変動をソースによって分割するために,減少したランク回帰を使用した.
主要な成果:
- 地元で共有された活動パターンは,行動やグローバルな活動とは無関係に,ポアソンピークの生成を超えた変動性を説明しました.
- 全球皮質活動により,行動要因よりもV1スパイクカウントの変動が有意に予測されました.
- 行動要因は少量のユニークな変動を説明し,世界的に予測可能なV1活動のサブスペースでした.
- ACAの光遺伝的混乱はV1の活動に影響を与え,ACAパターンはV1の変動を明らかにしない場合でも予測した.
結論:
- 他の皮質領域からのグローバルに共有された要因は,V1スパイクカウントの変動に大きく寄与する.
- 共有の変動のマイノリティは,局所V1回路に限定されています.
- 特にACAのような領域は 視覚皮質の処理を 調節する上で重要な役割を果たします
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