鼻のポリープを伴う重度のエオシノフィル性喘息と慢性鼻炎に関する欧州の専門家によるコンセンサス:OverSEA Delphi研究の結果
Claus Bachert1, Guy Brusselle2, José Antonio Castillo Vizuete3
1Department of Otorhinolaryngology, Head and Neck Surgery and the German Center of Diseases of the Upper Airway, University Hospital Münster, Münster, and the Department of Otorhinolaryngology, First Affiliated Hospital of Sun Yat-sen University, International Airway Research Center, Guangzhou, China.
The journal of allergy and clinical immunology. Global
|August 20, 2025
まとめ
エオシノフィル現象型 (SEA) の重度の喘息と鼻のポリープを伴う慢性鼻炎 (CRSwNP) の管理には,連携したアプローチが必要である. 専門家は,上部呼吸道状態を評価し,統合的な症状管理のために生物学的薬を使用することをお勧めします.
科学分野:
- 呼吸器医学
- アレルギー学
- 耳鼻喉科
背景:
- エオシノフィル現象型 (SEA) の重症性喘息は,特に鼻のポリープを伴う慢性鼻炎 (CRSwNP) で,管理が困難である.
- これらの複雑な患者を治療する医師の間で 協調されたケアが欠けていることが重要な問題です
研究 の 目的:
- SEAとCRSwNPの患者の管理のための現在の臨床慣行についての洞察を得るために.
- これらの患者のケアを最適化するための証拠に基づいた勧告を策定する.
主な方法:
- 2023年3月から6月までの2ラウンドのデルフィー調査.
- ヨーロッパ8カ国から205人の専門家 (肺科医,アレルギー科医,耳鼻科医) が参加しました.
- 評価,治療,フォローアップ,多学科管理に関する合意が≥70%と定義される.
主要な成果:
- CRSwNP (88%),アレルギー性鼻炎 (79%),およびSEA患者の他の上部呼吸道併発症に対する評価の重要性について高いコンセンサスがある.
- 診断 (82%),治療決定 (83%),およびフォローアップ (79%) に関する多学科アプローチの必要性について強く同意しています.
- 喘息とCRSwNPの両方の症状の管理に生物学的薬の有用性に関する重要な合意 (87%).
結論:
- オーバーSEAの研究は,CRSwNPでSEAを管理するための重要な勧告を提供します.
- SEA患者の上部呼吸道疾患,特にCRSwNPの評価を強調しています.
- 肺科医,アレルギー科医, otorhinolaryngologistsの間で協力的な,学際的なアプローチを推進します 合理的な患者のケアのために.
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