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Updated: Sep 8, 2025

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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ヒトの複雑な特徴に対する遺伝子用量応答曲線のバッファリングと非単調な行動

Nikhil Milind1, Courtney J Smith1, Huisheng Zhu2

  • 1Department of Genetics, Stanford University, CA, USA.

medRxiv : the preprint server for health sciences
|August 20, 2025
PubMed
まとめ

遺伝子発現に影響を与える遺伝的変異は,発現を増やすか減少させるかにかかわらず,特徴に類似した効果を示している. 遺伝子用量応答曲線 (GDRC) モデルは,特性の方向における体系的なバイアスを明らかにすることによって,このパラドックスを説明します.

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