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Updated: Sep 8, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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NLRP3炎症体の抑制剤の開発

Xin Zhou1, Steven H Liang1

  • 1Department of radiology and imaging sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
まとめ

この特許は,疾患の治療のための新しいNLRP3炎症体阻害剤を対象としています. これらの化合物は,免疫応答の重要な部分である3を含むNOD (核酸結合オリゴメリゼーション領域) 型の受容体ファミリーピリン領域を標的とする.

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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