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Updated: Sep 8, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

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ベンゾラクタムベースのGli阻害剤:合成と構造分析

Marianna Haddad1, Charles Wilber1, Jordan MacQueen1

  • 1Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
まとめ

研究者らは,がんの進行を標的としたベンゾラクタム系Gli阻害剤であるTPPBを開発した. このSmo独立化合物は,基礎細胞癌のモデルで抗腫瘍活性を示し,新しい治療戦略を提供している.

キーワード:
グリエジホグの信号経路基礎細胞がんベンゾラクタム阻害剤タンパク質キナーゼC

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