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Updated: Sep 8, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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小分子TREM2アゴニストの発見 改善されたインビトロ薬動学プロファイルと検証された標的の関与

Shaoren Yuan1, Farida El Gaamouch1, Sungwoo Cho1

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
まとめ

研究者はアルツハイマー病の新たなTREM2アゴニストであるC1を発見した. C1はマイクログリアルファゴシトーシスを強化し,改善された薬理学特性を示し,治療における有望なリードとなる.

キーワード:
アルツハイマー病トレム2コンピュータ化学薬物の発見薬理学

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