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Updated: Sep 8, 2025

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Published on: September 30, 2019

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仮想スクリーニングと分子動態シミュレーションによる新型FGFR1 V561M阻害剤の発見と特徴付け

Yang Lu1, Bizhi Li2, Xiaoli Zheng1

  • 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, China.

ACS medicinal chemistry letters
|August 20, 2025
PubMed
まとめ

新しい化合物である1457983-28-6は,FGFR1 V561M変異を効果的に抑制し,有望な新しい治療戦略を提供します. この発見は,FGFR1阻害剤耐性に対する第2世代の治療法の緊急の必要性に対応しています.

キーワード:
FGFR1機械学習分子動力学変異仮想スクリーニング

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