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Updated: Sep 8, 2025

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients
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Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

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選択的アミノ酸配合は,アニオン分泌を増強し,システィックフィブロシス変異の機能を回復します

Astrid Grosche1, Anusree Sasidharan1, Matthias Salathe2

  • 1Department of Radiation Oncology, University of Florida, Gainesville, FL, United States.

Frontiers in pharmacology
|August 20, 2025
PubMed
まとめ

新しいセレクトアミノ酸製剤 (SAA) は,変異の種類に関係なく,性線維症 (CF) 細胞におけるアニオン分泌を増強する. このSAA療法では,CFTR機能と呼吸道表面液体の恒常性を改善することが期待されています.

キーワード:
CFTR についてSLC26A9 についてアミノ酸クロリド分泌胞性線維症ヒトの気管上皮細胞

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