統合失調症患者の都市での育成と皮質の変形との関連
Vittal Korann1,2, Umesh Thonse3, Arpitha Jacob4
1Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
Indian journal of psychological medicine
|August 20, 2025
まとめ
都市部での育成は脳の発達に影響し 統合失調症のリスクも高めます この研究では 都市化が特定の脳領域の 皮質の回転変化と相関し 神経発達に及ぼす環境的影響を強調しています
科学分野:
- 神経科学
- 精神科
- 都市研究
背景:
- 都市部で育った人は 統合失調症のリスクが高くなります
- 都市環境と関連した 根本的な脳の変化は 十分に理解されていません
- 早期の脳発達のマーカーである皮質のジリフィケーションは,都市化に関連して調査されています.
研究 の 目的:
- 都市での育成が皮質の回転に及ぼす影響を調査する.
- 都市生活の影響を受ける 特定の脳の領域を特定する
- 神経発達に寄与する環境要因を理解する.
主な方法:
- 70人の健康な対照群と87人の統合失調症患者 (18~50歳) を含む.
- 生まれた場所と育った場所のデータを収集し,国勢調査データを用いて分類します.
- 都市化指数と脳MRIスキャンを分析して グラフィケーション指数 (GI) を計算した.
主要な成果:
- 都市化指数とGIは,左上辺回転,左側前頭回転,横側後頭回転で正の関連性が見られた.
- 統合失調症の診断と都市化の間の重要な相互作用は複数の脳領域で観察されました.
- 皮質のジリフィケーションは,都市での育成の度合いに大きく影響されます.
結論:
- 都市生活は脳の発達に大きな影響を与えます
- こうした環境の影響を理解することは 統合失調症の予防に不可欠です
- 都市計画や公衆衛生の戦略に役立つかもしれない
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