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Updated: Sep 8, 2025

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mTORと関連するシグナリングを標的とし,乳がん幹細胞の細胞死を誘発する

Kirti S Prabhu1, Zahwa Mariyam1, Syed A Rahman1

  • 1Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.

Cell biology international
|August 20, 2025
PubMed
まとめ

Torin- 2でmTOR/ AKT経路を標的にすると,乳がん幹細胞 (CSCs) の成長が効果的に抑制された. この二重のmTOR阻害はアポトーシスとオートファギーを誘発し,腫瘍細胞の生存率と幹細胞のマーカーを減少させた.

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