先天性心疾患の胎児における第2 trimesterにおける前頭葉発達障害を示すパラメータ

Qianqian Wang¹, Xiaoyan Gu¹, Jiancheng Han¹

¹Cardiac Ultrasound Medical Center, Beijing Key Laboratory of Maternal-Fetus Medicine in Fetal Heart Disease, Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing, China.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

|August 20, 2025

まとめ

先天性心疾患 (CHD) は,特に左側阻害性病変において,胎児の前頭葉の発達を阻害する. これは脳 perfusion 変化と胎盤の問題に関連している可能性があります.

科学分野:

胎児医学
心臓病科
神経発達

背景:

生まれつきの心臓病 (CHD) は胎児の発達に影響します
前頭葉の発達は認知機能に不可欠です
CHDにおける神経発達の初期マーカーの理解は重要です.

研究の目的:

異なるCHD現象型の胎児における前頭葉の発達と胎児の生体測定を調査する.
心臓病における胎児の生体測定と脳 perfusion パラメータの相関を分析する.
胎児における左側阻害性病変 (LSOL) と右側阻害性病変 (RSOL) の前頭葉発達を比較する.

主な方法:

心臓病と対照群の137人の胎児 (20~28週間の妊娠期) の遡及分析
CHD群をLSOLとRSOLフェノタイプに分割する.
前頭葉前後半径 (FAPD),後頭前半径 (OFD) およびドップラーパラメータの傾向スコアマッチングと評価.

主要な成果:

CHDの胎児は,対照群と比較してFAPDが著しく減少した.
LSOLグループは,最小のFAPDと低いFAPD/OFD比率,MCA-PI,およびCPRを示しました.
また,LSOL群ではUA-PIと平均UtA-PIが高く,輸血が変化したことを示した.

結論:

胎児の前頭葉の発達は,心臓病の胎児の第2期に障害がある.
この障害はLSOL群でより顕著です.
心臓病の胎児の前頭葉の発達障害に寄与する可能性があります.

キーワード:

脳について生まれつきの心臓病胎児前頭葉前頭葉の前後の直径神経発達超音波検査

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