炎症,線維症,および全身性硬化症における血管機能障害をターゲットにすること:食事と補完的および代替医療の役割

Veronica Balbuena Hurtado^1,2, Monique Hinchcliff^1,3, Navya Murugesan¹

¹Yale School of Medicine, Department of Medicine, Section of Rheumatology, Allergy & Immunology, New Haven.

Current opinion in rheumatology

|August 20, 2025

まとめ

食生活の変化と補足療法により,全身性硬化症 (SSc) の症状の管理に役立ちます. SSc患者に対する機能的食品と代替医療の有効性を確認するには,さらなる研究が必要である.

科学分野:

リウマトロジ
栄養学
統合医療

背景:

組織性硬化症 (SSc) の患者は,食事療法や補足療法について頻繁に尋ねる.
機能性食品と補完的・代替医療 (CAM) は,SScの補助的な治療法として検討されています.

研究の目的:

SSc管理のための食事介入,機能的な食品,CAMに関する既存の文献をレビューする.
これらのアプローチの有効性と安全性に関する現在の証拠を要約します.

主な方法:

食事のアプローチ (例えば,低FODMAP,地中海,ケトゲンダイエット) を調査する研究の文献検索.
サプリメント (例えば,オメガ-3,クルクミン),薬草,局所薬,ビタミンに関する研究のレビュー.
症状の軽減,微生物群の調節,および抗炎症効果に関する証拠の分析.

主要な成果:

低FODMAP,地中海,ケトジニックダイエットは,サンプルサイズが小さいSScにおける症状の軽減と微生物群の調節の可能性を示しています.
オメガ3脂肪酸を含むナイトレートと抗酸化サプリメントは,炎症と酸化ストレスを軽減します.
カルキュミンのようなハーブ製薬は,臨床前試験で抗線維剤の性質を示し,局所薬やビタミンが一般的に使用されているが,確固たる臨床試験は欠けている.

結論:

CAM,ダイエット介入,機能的な食品は,SScのサポート療法としての可能性を示しています.
SSc管理におけるこれらの介入の決定的な証拠を確立するには,より質の高い臨床研究が不可欠です.

キーワード:

補完医学と代替医学ダイエットエクスポソームサプリメント組織性硬化症

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