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関連する概念動画

Carbon Skeletons01:12

Carbon Skeletons

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Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
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Overview of Nitrogen Metabolism01:20

Overview of Nitrogen Metabolism

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Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of  ammonia, ammonium ions, nitrate, nitrite, or  nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this...
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RNA Editing02:23

RNA Editing

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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Naming Skeletal Muscles01:19

Naming Skeletal Muscles

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The naming of the approximately 700 muscles in the human body is based on a set of criteria designed to provide descriptive information about each muscle, making it easier to identify and remember them.
The key factors used in naming muscles include:
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Inorganic Nitrogen Assimilation01:22

Inorganic Nitrogen Assimilation

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Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme...
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Construction of a Realistic, Whole-Body, Three-Dimensional Equine Skeletal Model using Computed Tomography Data
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窒素原子操作による骨格編集

Linlin Ding1, Yang Fan1, Hongjian Lu1,2

  • 1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China. hongjianlu@nju.edu.cn.

Chemical Society reviews
|August 20, 2025
PubMed
まとめ
この要約は機械生成です。

窒素原子編集 (N原子編集) は,新しい分子変換を可能にすることで,合成化学を進歩させる. このレビューは,医薬品化学と材料科学における最近の突破と応用をカバーしています.

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Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Construction of a Realistic, Whole-Body, Three-Dimensional Equine Skeletal Model using Computed Tomography Data
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Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

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科学分野:

  • 合成化学
  • 有機化学
  • 薬剤化学

背景:

  • 窒素原子は 生物活性分子や合成ビルの構成要素において 極めて重要です
  • 窒素原子編集 (N-原子編集) は,その有用性のために顕著になった.
  • 最近の進歩は,N原子編集の範囲とアプリケーションを拡大しました.

研究 の 目的:

  • N原子編集の方法論の包括的な概要を提供する.
  • 機械的洞察と歴史的発展について議論する.
  • 生物活性分子と材料の合成における応用を強調する.

主な方法:

  • N原子編集技術に関する最近の文献のレビュー.
  • 機械的な経路の詳細な議論
  • 医薬品化学と材料科学における応用分析

主要な成果:

  • 過去5年間,新しいN原子編集方法論の 重要な進歩.
  • N原子編集の変革の可能性を様々な分野で示した.
  • 複雑な分子を合成し改造する例です.

結論:

  • N原子編集は,拡張アプリケーションを持つ強力なツールです.
  • 機械的理解は将来の研究のための概念的ツールを提供します.
  • N原子編集の将来的な展望と課題が概説されています.