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Updated: Sep 10, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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生体内での腫瘍増殖制御は,一般制御による 非抑制性2標的薬によるキナーゼ活性化による結果

Feven Tameire1, Paulina Wojnarowicz2, Crissy Dudgeon1

  • 1HiberCell, Inc., Boston, MA, United States.

Molecular cancer therapeutics
|August 20, 2025
PubMed
まとめ

低用量のGCN2活性化剤は阻害剤ではなく,統合ストレス反応を活性化することで腫瘍の成長を抑制する. この予期せぬ発見は,GCN2を標的とするがん治療法の臨床開発に影響を与えます.

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