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軽視されている病原体:コリーネバクテリア

Brooks I Mitchell^1,2, John E Markantonis³

¹Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Journal of clinical microbiology

|August 20, 2025

まとめ

非ディフテリアコリーネバクテリアの種は,血流からデバイスに関連するさまざまな感染症を引き起こす病原体としてますます認識されています. マトリックス関連レーザー脱吸収/イオン化飛行時間質量スペクトロメトリを用いた正確な識別は,臨床微生物学の研究室にとって極めて重要です.

科学分野:

医学微生物学
感染症
臨床診断

背景:

歴史的に,C.ディフテリアを除くコリーネバクテリアの種は非病原性と考えられていた.
近年では様々な感染症を引き起こす病原性非ディフテリア菌コリーネバクテリアの種が増加しています
これらのバクテリアは特定の臨床シナリオと解剖学的部位に関連しています

研究の目的:

ディフテリア以外のコリーネバクテリアの新興病原性作用を強調する.
臨床微生物学の正確な識別と報告の重要性を強調する.
これらの生物を特定するMALDI-TOF MSの有用性について議論する.

主な方法:

臨床症例と微生物学的研究の文献レビュー
特定のCorynebacterium種に関連した感染症の分析
MALDI-TOF MSを含む診断方法についての議論

主要な成果:

C. ストライアタムとC. ジェイケイウムは血流や骨格の感染症を引き起こす
C. macginleyiとC. otitidisは目と耳の感染症に関与しています.
C.プロピンクラム/プセドディフテリチウム群は肺炎を引き起こし,C.ウレアリチウム群は膀炎を引き起こし,C.ボディンステディ群は乳房炎と関連している.
エリトラズマのような皮膚疾患はC. aurimucosum/minutissimumと関連しています.
バイオフィルム形成は,装置に関連した感染症 (キャセター,シャント,義肢) を引き起こします.

結論:

非ディフテリアコリーネバクテリアの種は重要な病原体であり,臨床的認識が必要である.
特にMALDI- TOF MSでは,患者の治療に最適化された検査が不可欠です.
コリネバクテリア関連感染症の適切な治療と管理に役立つ正確な識別

キーワード:

コリーネバクテリアコリネフォームグラム陽性棒ディフテリア

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