精神病的な経験の顕著さ:一般人口の神経相関関係
Maja Neidhart1,2,3, Gina-Isabelle Henze1,3, Bob O Vogel1
1Department of Psychiatry and Psychotherapy, CCM, Charité Universitätsmedizin Berlin, Berlin, 10117, Germany.
Schizophrenia bulletin
|August 20, 2025
まとめ
サブクリニカルな精神病的な経験は,特に背面前帯状皮質と前帯状皮質を含む,突起ネットワーク (SN) の機能的接続性の高まりと関連しています. これは,SN
科学分野:
- 神経科学
- 精神科
- 認知科学
背景:
- 精神病的な経験 (PEs) は,一般の集団でサブクリニック的に発生します.
- 異常突起仮説は,突起ネットワーク (SN) がPEsの鍵であると仮定する.
- 背面前帯状皮質 (dACC) と前帯状皮質 (AI) に固定されたSNは,内側と外側の世界を調整します.
研究 の 目的:
- 一般集団のサンプルでSNの機能的接続性 (FC) を調査する.
- PEsの開発と維持におけるSNの役割を検討する.
- SNの機能的な接続性を通してPEsの病因を理解する.
主な方法:
- 84人の一般集団からの休息状態機能的接続性 (rsFC) のデータ.
- 精神体験のコミュニティ評価-ポジティブスケール (CAPE-15) を使用してPEsを定量化しました.
- ENIGMA HALFpipeとFSLを用いてdACCとAIのシードベースの相関分析を行い,FDRの修正を行った.
主要な成果:
- 増加したPEsは,主要なSNノード (AI,dACC) の有意なハイパーコネクティビティと相関する.
- SNノードはデフォルトモード,中央エグゼクティブ,視覚,聴覚,腹部注意ネットワークへのハイパー接続性を示しました.
- 特定のハイパーコネクテッド領域にはタラムス,パラヒポキャンパスの回転,および正面の極が含まれています.
結論:
- この発見は,一般集団におけるPEsの発展と維持におけるSNの重要な役割を裏付けています.
- SNのハイパーコネクティビティは,無関係な刺激に目立つことの根拠となることがあります.
- これは,PEsの個体に対する 認知的な説明への注意と探求を 示唆している.
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