早期発症の胃がんの世界的な負担プロファイル,傾向,原因
Xueyang Zhang1, Boao Gao1, Wei Wang2
1International Medical College, Chongqing Medical University, Chongqing 400016, China.
Cancer biology & medicine
|August 20, 2025
まとめ
早期発症胃がん (EOGC) の負担は世界的に減少したが,格差は残っている. 公衆衛生の取り組みは 喫煙や塩分が多い食事に焦点を当てて 異なる集団に合わせた介入を行う必要があります
科学分野:
- 腫瘍学
- 流行病学について
- 公衆衛生
背景:
- 早期発症した胃がん (EOGC) は,世界的に健康上の懸念が高まっています.
- EOGCの負担とリスク要因を理解することは 効果的な介入に不可欠です
研究 の 目的:
- 1990年から2021年までの EOGC のグローバル,地域,および国の負担を評価する.
- リスク要因を特定し,差異を分析する.
- 2040年までのEOGC負担の将来の傾向を予測する.
主な方法:
- 発生率,流行率,死亡率,および DALY を用いて定量化された EOGC 負担
- 年齢で標準化された割合を計算し,リスク要因の貢献を分析した.
- ベイジアン年齢周期コホートモデルを用いて将来の傾向を推定した.
主要な成果:
- 2021年,EOGCは125,000人の新規症例,336,000人の流行症例,78,000人の死亡,および386万人のDALYを引き起こしました.
- 世界的な年齢基準の割合は1990年から2021年にかけて減少したが,地域間の格差は拡大した.
- 喫煙と塩分が多い食生活が主なリスク因子で 地域や性別が大きく異なっています
結論:
- EOGCの負担は,世界的に減少したものの,地域,年齢,性別の差が続いている.
- 公共衛生の戦略では 喫煙の予防と禁煙を食塩の摂取量削減と統合すべきです
- EOGCの複合的な負担に対処するために,ターゲットを絞った介入が必要である.
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