Search

Search

このページは機械翻訳されています。他のページは英語で表示される場合があります。 View in English

ホーム
...
研究分野生物医学と臨床科学腫瘍学とがん発生予測・予測マーカー
コランジオカルシノーマにおけるXPC rs2228001単核酸多型性の予測値

コランジオカルシノーマにおけるXPC rs2228001単核酸多型性の予測値

Guanwu Wang ^1,2, Anna Mantas ^1,3, Dong Liu ¹, Tarick M Al-Masri ^1,4, Smiths Sengkwawoh Lueong ^5,6, Jens Siveke ^5,6, Tom Luedde ⁷, Tom F Ulmer ^1,3,8, Iakovos Amygdalos ¹, Florian W R Vondran ¹, Georg Lurje ⁹, Ulf Peter Neumann ^1,3,8, Lara R Heij ^3,10, Jan Bednarsch ^1,3

Guanwu Wang ^1,2, Anna Mantas ^1,3, Dong Liu ¹

¹Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
²Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
³Department of Surgery and Transplantation, University Hospital Essen, Essen, Germany.
⁴University of Applied Science Aachen, Aachen, Germany.
⁵German Cancer Consortium (DKTK), Partner Site Essen, a Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany.
⁶Bridge Institute of Experimental Tumor Therapy (BIT) and Division of Solid Tumor Translational Oncology (DKTK), west German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
⁷Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
⁸Department of Surgery, Maastricht University Medical Centre (MUMC), Maastricht, the Netherlands.
⁹Department of Surgery and Transplantation, University Hospital Heidelberg, Heidelberg, Germany.
¹⁰Institute of Pathology, University Hospital Essen, Essen, Germany.

⁰Department of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.

Liver International : Official Journal of the International Association for the Study of the Liver +

|

2025年8月20日

関連する実験動画

These videos have been matched automatically. Contact us if they are not relevant.

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

See all related videos

PubMedで要約を見る

まとめ

この要約は機械生成です。

XPC rs2228001のようなDNA修復遺伝子の単一核酸多型化 (SNP) は,手術後の胆管がん (CCA) 患者のアウトカムを予測することができます. この発見は,CCA患者のための個別化された術後ケア戦略の開発に役立ちます.

科学分野

腫瘍学
遺伝学
分子生物学

背景

コランジオカルシノーマ (CCA) は,特に東南アジアで発生率と死亡率が上昇する主要な肝がんです.
外科的切除は局所的なCCAの重要な治療法ですが,早期再発は一般的です.
手術後の管理と追跡をパーソナライズするツールが必要です

研究の目的

CCA手術後の患者の予後を予測するために,DNA修復遺伝子における単一ヌクレオチドポリモルフィズム (SNPs) の臨床的有用性を調査する.
特定のSNP (ERCC5 rs1047768,APEX1 rs1130409,PARP1 rs1805414,XPC rs2228001,ERCC5 rs873601) がCCA患者の生存結果に与える影響を評価する.

主な方法

手術を受けた肝内 (iCCA) と外側 (pCCA) 胆管がん患者229人のコホートを分析した.
カプラン- メイヤー分析と多変量コックス回帰を用いて,SNPと生存の関連性を評価した.

主要な成果

XPC rs2228001のTTゲノタイプは,iCCA患者における長期無再発生存期 (RFS),がん特異生存期 (CSS),全生存期 (OS) と有意に関連していた.
pCCA患者では,XPC rs2228001のTT遺伝子型も,CSSの改善のための独立した予後要因として機能しました.

結論

DNA修復遺伝子,特にXPC rs2228001の単核酸多型化 (SNPs) は,胆管がんの予後に影響を及ぼします.
これらの遺伝子マーカーは,CCAの患者特有の術後管理とフォローアップ戦略を改善する可能性を秘めています.

キーワード:

XPC rs2228001 についてコランジオセルラー癌 DNA 修復遺伝子腫瘍学的結果シングルヌクレオチドポリモルフィズム

関連する実験動画

自動的に一致したビデオです Contact us もしそれらが関連していない場合

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

See all related videos

関連する概念動画

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

Share

X
Facebook
LinkedIn
YouTube

ABOUT JoVE

Overview
Leadership
Blog
JoVE Help Center

AUTHORS

Publishing Process
Editorial Board
Scope & Policies
Peer Review
FAQ
Submit

LIBRARIANS

Testimonials
Subscriptions
Access
Resources
Library Advisory Board
FAQ

RESEARCH

JoVE Journal
Methods Collections
JoVE Encyclopedia of Experiments
Archive

EDUCATION

JoVE Core
JoVE Business
JoVE Science Education
JoVE Lab Manual
Faculty Resource Center
Faculty Site

Terms & Conditions of Use
Privacy Policy
Policies