レビュー記事: 代謝機能障害に関連するステアトス性肝疾患の発症と進行に対するアルコール摂取の影響

Yunxuan Lei¹, Yixuan Zhu¹, Wenjing Ni²

¹Department of Infectious Disease, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Alimentary pharmacology & therapeutics

|August 20, 2025

まとめ

アルコール摂取は,代謝機能不全に関連した脂肪性肝疾患 (MASLD) を悪化させ,肝臓の脂肪と炎症を強める. この相互作用を理解することは,MASLDのパーソナライズされた治療とリスク評価の鍵です.

科学分野:

ヘパトロジー
代謝障害
胃腸内科

背景:

メタボリック機能障害に関連した脂肪性肝疾患 (MASLD) は,肥満やインスリン抵抗性などの代謝問題に関連した広範な肝疾患です.
アルコールの影響に関する新たなデータにより,MASLDはアルコール関連肝疾患とは別々に見られている.

研究の目的:

アルコールの摂取がMASLDの進行にどのように影響するかを調査する.
アルコール摂取によるMASLD患者におけるメカニズム,臨床効果,およびリスクの階層化に関する課題を調査する.

主な方法:

MASLDにおける代謝機能障害とのアルコールの相互作用を調査した研究の記述的レビュー.
2025年6月までの疫学とメカニズムの研究も含まれています.

主要な成果:

適度なアルコール摂取は,酸化ストレス,脂質代謝の変化,腸内不活性症によって肝硬変を悪化させる.
アルコールは炎症を助長し,MASLDが脂肪肝炎,線維症,肝硬変に進行するのを加速します.
投与量依存のアルコール摂取は,肥満と代謝症候群と肝臓疾患の重症性に相関する効果を示しています.

結論:

アルコール摂取は複雑なメカニズムで MASLDの進行を加速します
アルコール消費の標準化された評価は,効果的なMASLDリスクの階層化とパーソナライズされた治療に不可欠です.

キーワード:

アルコール摂取量代謝機能障害関連脂肪肝脂肪酸性肝疾患

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