Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Dual responsive enzyme mimicking activity of AgX (X=Cl, Br, I) nanoparticles and its application for cancer cell detection.

ACS applied materials & interfaces·2014
Same author

Naphthoquinone-directed C-H annulation and C(sp³)-H bond cleavage: one-pot synthesis of tetracyclic naphthoxazoles.

The Journal of organic chemistry·2014
Same author

Pulmonary toxicity in mice following exposure to cerium chloride.

Biological trace element research·2014
Same author

Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy.

Journal of pediatric surgery·2014
Same author

Glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and acute leukemia risk in Asians: a meta-analysis.

Asian Pacific journal of cancer prevention : APJCP·2014
Same author

Influence of casting solvent on phenyl ordering at the surface of spin cast polymer thin films.

Journal of colloid and interface science·2014

関連する実験動画

Updated: Jun 13, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K

多層機能的接続性ハイパーネットワークに基づく軽度の肝臓脳症の特定

Chi Zhang1, Fei Liu1, Yue Cheng2,3

  • 1Tianjin Key lab of cognitive computing and application, College of Intelligence and Computing, Tianjin University, Yaguan Road, Tianjin, 300350, Tianjin, China.

Neuroinformatics
|August 20, 2025
PubMed
まとめ

この研究は,早期の軽度の肝臓脳症の診断のために休息状態のfMRIを用いた新しい高レベルのハイパー接続性ネットワークを導入します. この方法は脳のネットワークの変化を効果的に特定し 診断の正確性と解釈性を改善します

キーワード:
脳疾患の診断肝臓脳症ハイパー接続ネットワークマルチレベル小規模サンプルデータセット

さらに関連する動画

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.0K

関連する実験動画

Last Updated: Jun 13, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.3K
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

8.0K

科学分野:

  • 神経科学
  • 医療用イメージング
  • ネットワーク科学

背景:

  • 軽度の肝臓脳症 (MHE) の早期診断は,治療と進行を防ぐために極めて重要です.
  • 神経学的障害に対する既存の脳のハイパー接続ネットワークモデルは,低レベルの時間同期のみを考慮することで制限されています.

研究 の 目的:

  • MHEの診断を改善するために,静止状態の機能的磁気共鳴画像 (rs-fMRI) を使用する新しいハイレベルハイパー接続ネットワークを提案する.
  • 神経学的障害の診断能力を高めるため 脳の領域間の複雑な相互作用を捉えるために

主な方法:

  • rs-fMRIデータからハイパーコネクティビティの多層ネットワークの構築
  • ノードハイパー度,ハイパーエッジグローバル重要度,ハイパーエッジ分散特性の抽出と組み合わせ
  • 特徴の選択と分類のためにグラデーションの強化決定ツリーを適用し,オフワンアウトクロス検証を使用して検証します.

主要な成果:

  • 提案された方法は,MHEの診断に相当なパフォーマンスを示しました.
  • 独立した自閉症スペクトル障害 (ASD) データセットでの検証により,モデルの一般化能力が確認されました.
  • 重要な脳領域とハイパーエッジの特徴を特定することで 診断モデルが解釈可能になった.

結論:

  • この新しいハイパー接続ネットワークは MHEの診断に有効です
  • この方法は,他の神経学的障害に適用できる強力な汎用性を示しています.
  • このアプローチは,MHEに関連した脳ネットワークの変化に関する貴重な洞察を提供します.