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Updated: Sep 10, 2025

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
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Published on: January 22, 2021

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SPARCは,アグレッシブな分子がん関連フィブロブラストシグネチャーと,大腸がんにおけるCSF1媒介がんの侵入を表すCOL1A1/COL3A1発現を誘導する

Yusuke Nie1, Yoshiki Fujiyama1, Shumpei Shibaki1

  • 1Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Annals of surgical oncology
|August 20, 2025
PubMed
まとめ

スパークは腫瘍の微小環境 (TME) を変えて結腸直腸がんの転移を促進する. SPARCとその関連遺伝子をターゲットにすると 攻撃的な癌の治療戦略が生まれます

キーワード:
癌の転移サイトカインインターフェロン予測スパーク

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