プロモーターおよび強化剤に依存するコヘシン負荷は,長距離リコンビネーションのためのTcrbロシウムの折りたたみに染色体のループを開始する

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Updated: Sep 10, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

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Brittney M Allyn1, Katharina E Hayer2, Clement Oyeniran3

  • 1Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Cell reports
|August 20, 2025
PubMed
まとめ

コヘシン媒介の染色体ループは,抗原受容体遺伝子組立を誘導する. この研究は,Tcrbロカス全体でのコヘシン負荷とループエクストルーションが,多様なT細胞受容体レパートリーを組み立てるのに不可欠な長距離コンタクトを作成する方法を示しています.

キーワード:
CP: 分子生物学V(D) J 再結合染色体ループコヘシンメディエイト・ループ・エクストルーションゲノムトポロジー

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