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Updated: Sep 10, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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C19orf12はミトコンドリア機能を阻害し,非小細胞肺がんにおけるメトホルミンの抗腫瘍効果を強化する

Ran Liu1, Meng Zhao2, Xinrui Zhang1

  • 1Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease of the Ministry of Education, Collaborative Innovation Center of the Ministry of Education for Medical Epigenetics, Department of Immunology, Tianjin Medical University, Tianjin 300070, China.

Cell reports
|August 20, 2025
PubMed
まとめ

染色体19の開いた読み取り枠12 (C19orf12) は,非小細胞肺がん (NSCLC) の有酸素糖解を駆動する. C19orf12の上昇は予後が悪いことを予測し,ミトコンドリア呼吸を阻害することによってメトホルミンの有効性を高めます.

キーワード:
C19orf12 についてCP: がんについてCP: 代謝LRPPRC についてNSCLC についてグリコリスメタスタシスメトホルミンミトコンドリア機能

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