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Updated: Sep 10, 2025

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CX3CR1+マクロファージは,HSCと相互作用し,CD8+T細胞抑制を通じてHCCを促進する

Jong-Min Jeong1, Sung Eun Choi1, Young-Ri Shim1

  • 1Laboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.

Hepatology (Baltimore, Md.)
|August 20, 2025
PubMed
まとめ

肝臓の星状細胞 (HSC) は,CX3CR1+マクロファージを活性化することによって,肝細胞癌 (HCC) を促進する. HSCからのレチノイドはこれらのマクロファージでアルギナゼ-1を誘導し,CD8+T細胞を抑制し,腫瘍の成長を促します.

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