関連する実験動画

Updated: Sep 10, 2025

Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting LIMACS: a Novel Method to Analyze Protein-lipid Interaction
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Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting LIMACS: a Novel Method to Analyze Protein-lipid Interaction

Published on: April 26, 2011

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脂質クリニックでのリソソーム酸リパース欠乏症のスクリーニング

Zenia Brasil1, Francisco Antonio H Fonseca1,2, Marco Antonio Curiati3

  • 1Disciplina de Cardiologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP - Brasil.

Arquivos brasileiros de cardiologia
|August 20, 2025
PubMed
まとめ

リン酸性脂質酵素欠乏症 (LAL- D) のスクリーニングは,脂質不全症患者において困難です. 臨床的アルゴリズムは識別を助けますが,LAL-Dは,その希少性と重複する症状のために,しばしば排除の診断のままです.

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Defining Substrate Specificities for Lipase and Phospholipase Candidates

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関連する概念動画

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
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Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
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