ハンティントン病の患者のスピーチプロファイル:認知,臨床,社会人口学的相関
Nathália Vescia Bauer1, Maria Eduarda Soares Machado2, Maiara Laís Mallmann Kieling Peres2
1Curso de Fonoaudiologia, Universidade Federal do Rio Grande do Sul - UFRGS - Porto Alegre (RS), Brasil.
CoDAS
|August 20, 2025
まとめ
ハンチントン病 (HD) の発話障害は,発音,発音,呼吸に影響する運動の低下と関連しています. これらの言語の変化は 病気の進行を予測する バイオマーカーとして役立つかもしれません
科学分野:
- 神経科学
- スピーチ・ランゲージ・パスロジー
背景:
- ハンチントン病 (HD) は進行性神経変性疾患である.
- 発声障害はHDでよく見られますが 詳細な特徴づけが必要です
研究 の 目的:
- ハンチントン病 (HD) の患者を対象にスピーチプロファイルを特徴づける.
- HDの認知および臨床的側面と 言語障害を関連付けること
- HD患者と健康な対照群の言語機能を比較する.
主な方法:
- HDと診断された症状のある個人を含め,健康な対照群に匹配しました.
- ハンチントン病評価尺度で 臨床データを収集しました
- 聴覚的知覚の評価と様々なスピーチタスクの音響分析を用いてスピーチを評価する.
主要な成果:
- HD患者の7人に4人は 軽度から重度まで 発症した.
- 言語障害はHD患者の全体的な運動低下と有意に相関していました.
- HDの被験者はコントロールと比較して音声,呼吸,発音の有意な欠陥を示しました.
結論:
- 発音 発音 呼吸 発音 呼吸 発音 発音 呼吸 発音 発音 呼吸 発音 発音 発声 発声 発声 発声 発声 発声 発声
- 運動言語の欠陥は病気の全体的な運動進行と関連しています.
- ハンチントン病の進行を予測する バイオマーカーとしての可能性を示しています
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