Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

1.1K
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
1.1K
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

204
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
204
Methods of Classification and Identification01:28

Methods of Classification and Identification

2.3K
Bacterial identification relies on a diverse array of techniques to classify and understand microorganisms, each tailored to uncover specific characteristics. Traditional morphological approaches, while still valuable, are limited for closely related or structurally simple organisms. Modern methods integrate biochemical, serological, genetic, and advanced molecular tools to achieve greater accuracy.Morphological and Biochemical TechniquesMorphological characteristics, such as cell shape and...
2.3K
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

77
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
77

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Exploring the Impact of E‑Waste Exposure on Childhood Blood Pressure: Metabolomics Analysis and Risk Prediction.

Environment & health (Washington, D.C.)·2026
Same author

Integrated Human Organic Pollutant Exposome and Metabolome Analysis Reveals Biomarkers and Health Risks from Electronic Waste Exposure.

Environmental science & technology·2026
Same author

Construction of Models To Predict the Effectiveness of E-Waste Control through Capture of Volatile Organic Compounds and Metals/Metalloids Exposure Fingerprints: A Six-Year Longitudinal Study.

Environmental science & technology·2023
Same author

Soil water-stable aggregates and microbial community under long-term tillage in black soil of Northern China.

Ecotoxicology (London, England)·2021
Same author

Comparison of Three Motor Subtype Classifications in <i>de novo</i> Parkinson's Disease Patients.

Frontiers in neurology·2021
Same author

Effects of bicornuate uterus on pregnancy and obstetric outcomes of in vitro fertilization / intracytoplasmic sperm injection.

European journal of obstetrics, gynecology, and reproductive biology·2021

関連する実験動画

Updated: May 3, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.7K

ビスフェノールアナログの代謝シグネチャーの特定:新しい代替品の迅速な毒性スクリーニングへの影響

Hong-Xuan Kuang1, Ye Liu1, Lei Yan1

  • 1Key Laboratory of Environmental Pollution Health Risk Assessment, Ministry of Ecology and Environment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China.

Environmental science & technology
|August 20, 2025
PubMed
まとめ
この要約は機械生成です。

ビスフェノールA代用品 (BP) は,毒性の評価が不十分であるため,汚染の危険性があります. 新しいヒスティジン/キヌレニン比バイオマーカーは,BP暴露を効果的に識別し,迅速な毒性スクリーニングを助けます.

キーワード:
バイオマーカーバイオ変換代謝障害メタボロミクス

さらに関連する動画

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.2K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

470

関連する実験動画

Last Updated: May 3, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.7K
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.2K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

470

科学分野:

  • 環境化学
  • 毒理学について
  • メタボロミクス

背景:

  • ビスフェノールA代替品 (BPs) は包括的な毒性データがないため,環境への懸念が生じています.
  • BPの毒性に対する迅速なスクリーニングツールの開発は,公衆衛生と環境安全にとって極めて重要です.

研究 の 目的:

  • ビスフェノルA代用品 (BP) の迅速な毒性スクリーニングと評価のための特定のバイオマーカーを開発する.
  • BPs暴露によって引き起こされる代謝障害と毒性メカニズムを調査する.

主な方法:

  • 非標的および標的メタボロミクスは,BP曝露に対する血代謝物質のプロフィールを用いた.
  • BPsとその代謝産物のホルモン受容体との結合親和性を評価するために,分子ドッキングが利用されました.
  • 肝臓機能,腎臓機能,代謝指数の分析を行った.

主要な成果:

  • キヌレニンとヒスティディンは一般的な代謝シグネチャーとして特定されました.
  • ヒスティジン/キヌレニンの比率は,BP曝露を区別するために高い予測精度 (AUC: 0. 937) を示した.
  • ホルモン受容体への結合が弱い代謝変異剤 (MTP) は,代謝干渉の減少と相関しており,解毒能力の役割を示しています.

結論:

  • ヒスティジン/キヌレニンの比率は,新興BPの迅速な毒性評価のための有望なバイオマーカーとして機能します.
  • BPsによる代謝障害は,それらの代謝解毒経路によって影響されます.
  • BPの毒性およびバイオマーカーの開発に関するさらなる研究が必要である.