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Updated: Sep 10, 2025

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

523

E3リガスの未知結合ポケットの発見は,FBW7アロステリックモジュレータの識別につながった

Míriam Martínez-Cartró1,2, Álvaro Serrano-Morrás1,2, Andrea Bertran-Mostazo1,2

  • 1Departament de Farmàcia i Tecnologia Farmacéutica, i Fisicoquímica. Facultat de Farmàcia i Ciències de l'Alimentació Universitat de Barcelona, Barcelona, 08028, Spain.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 20, 2025
PubMed
まとめ

研究者は,標的型タンパク質の分解に不可欠なE3リガゼの薬効性アロステリックポケットを特定しました. FBW7を標的とした新しい小分子を発見し,c-MYCとc-JUNタンパク質の分解を強めた.

キーワード:
アロスター主義E3リガゼ結合性/薬物性薬物の発見標的型タンパク質の分解

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