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Updated: Sep 10, 2025

A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
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Nrf2の薬理学的活性化: スタチンとメトホルミンの酸化ストレスに対する心臓保護効果

Sinenhlanhla X H Mthembu1, Sithandiwe E Mazibuko-Mbeje2, Khanyisani Ziqubu2

  • 1Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, 7505, South Africa; Department of Biochemistry, North-West University, Mafikeng Campus, Mmabatho, 2735, South Africa.

Atherosclerosis
|August 20, 2025
PubMed
まとめ

核因子エリソイド2関連因子2 (Nrf2) 経路の強化は,血脂不全に関連した心血管合併症に対する新しい治療戦略を提供します. ステチンやメトホルミンのようなよく使われる薬は,Nrf2の活動を間接的にサポートし,酸化ストレスを軽減し,心臓の機能を改善します.

キーワード:
抗酸化物質脱脂症メトホルミンNrf2の活性化酸化ストレススタチン

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